Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury
Year: 2023
Type: article
Abstract: In this study, we used diffuse optics to address the need for non-invasive, continuous monitoring of cerebral physiology following traumatic brain injury (TBI). We combined frequency-domain and broadband diffuse optical spectroscopy with diffuse correlation spectroscopy to monitor cerebral oxygen metabolism, cerebral blood volume, and cerebral water content in an established adult swine-model of impact TBI. Cerebral physiology was monitored before and after TBI (up to 14 days post injury). Overall, our results suggest that non-invasive optical monitoring can assess cerebral physiologic impairments post-TBI, including an initial reduction in oxygen metabolism, development of cerebral hemorrhage/hematoma, and brain swelling.
Source: Biomedical Optics Express
DOI: 10.1364/boe.486363
Authors: Rodrigo M. Forti, Lucas J. Hobson, Emilie J. Benson, Tiffany S. Ko, Nicolina R. Ranieri, Gerard Laurent, M. Katie Weeks, Nicholas J. Widmann, Sarah Morton, Anthony M. Davis, Takayuki Sueishi, Yuxi Lin, Karli S. Wulwick, Nicholas Fagan, Samuel S. Shin, Shih-Han Kao, Daniel J. Licht, Brian R. White, Todd J. Kilbaugh, Arjun G. Yodh, Wesley B. Baker
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,913
OpenAlex ID: W4365448142