Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the expression of histone lysine N-methyltransferase 2D (KMT2D) in gastric cancer patients and its relationship with the prognosis. METHODS: A total of 126 gastric cancer patients admitted to Hubei Provincial Hospital of TCM from January 2014 to June 2017 were selected as the research subjects, and patients' clinical data were analyzed retrospectively. First, the KMT2D mRNA or protein expression in the patient's tissue was detected using quantitative real-time PCR or immunohistochemistry. Afterwards, the relationship between the KMT2D protein expression and the prognosis of patients was analyzed using a Kaplan-Meier curve. Also, the predictive value of the KMT2D mRNA and protein expression for the prognosis and death rate of gastric cancer patients was evaluated using a receiver operating characteristic curve. Finally, the risk factors for poor prognosis and death of the gastric cancer patients were analyzed using a Cox regression analysis. RESULTS: <0.05). CONCLUSION: KMT2D is highly expressed in gastric cancer tissue and it is expected to be a potential biomarker for predicting the poor prognosis of gastric cancer patients.
Source: PubMed Central
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4365478949