Clinical and prognostic significance of long non-coding RNA CRNDE expression in severe pneumonia and its correlation with inflammatory factor levels.
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the clinical and prognostic significance of long non-coding RNA (lncRNA) CRNDE expression in severe pneumonia and its correlation with the levels of inflammatory factors. METHODS: In this retrospective study, 86 patients with severe pneumonia were selected as the observation group (OG), and 70 patients with non-severe pneumonia were selected as the control group (CG). The expression of lncRNA CRNDE was measured by real-time fluorescence quantitative reverse transcription polymerase chain reaction. The relationship between lncRNA CRNDE expression and clinical characteristics and prognosis of patients was analyzed. The correlation between lncRNA CRNDE expression and the levels of inflammatory factors related to severe pneumonia was also analyzed. RESULTS: <0.001). CONCLUSIONS: lncRNA CRNDE is highly expressed in the serum of patients with severe pneumonia and is an independent risk factor for the poor prognosis of these patients. The expression of lncRNA CRNDE is also positively correlated with the levels of inflammatory factors in such patients, which can be used for the clinical detection of severe pneumonia.
Source: PubMed Central
Authors: Miaomiao Peng, Lei Ma
Institution: Central Hospital of Zibo
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4365483433