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Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Year: 2023

Type: article

Abstract: Immune Engineering In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co-workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease-protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression.

Source: Advanced Science

DOI: 10.1002/advs.202370064

Authors: David A. McBride, Matthew D. Kerr, Wade T. Johnson, Anders Nguyen, Martina Zoccheddu, Mina Yao, Edward B. Prideaux, Nicholas C. Dorn, Wei Wang, Mattias N.D. Svensson, Nunzio Bottini, Nisarg J. Shah

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,720

OpenAlex ID: W4365505182

FWCI:

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