Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Year: 2023
Type: article
Abstract: Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette-Guérin (BCG) delivery is the only licensed vaccine against tuberculosis; however, it offers little protection from pulmonary tuberculosis in adults and is contraindicated in people living with HIV. Intravenous BCG confers protection against Mtb infection in rhesus macaques; we hypothesized that it might prevent tuberculosis in simian immunodeficiency virus (SIV)-infected macaques, a model for HIV infection. Here intravenous BCG-elicited robust airway T cell influx and elevated plasma and airway antibody titres in both SIV-infected and naive animals. Following Mtb challenge, all 7 vaccinated SIV-naive and 9 out of 12 vaccinated SIV-infected animals were protected, without any culturable bacteria detected from tissues. Peripheral blood mononuclear cell responses post-challenge indicated early clearance of Mtb in vaccinated animals, regardless of SIV infection. These data support that intravenous BCG is immunogenic and efficacious in SIV-infected animals.
Source: Nature Microbiology
Authors: Erica C. Larson, Amy L. Ellis-Connell, Mark A. Rodgers, Abigail K. Gubernat, Janelle L. Gleim, Ryan V. Moriarty, Alexis J. Balgeman, Cassaundra L. Ameel, Solomon Jauro, Jaime A. Tomko, Kara B. Kracinovsky, Pauline Maiello, H. Jake Borish, Alexander G. White, Edwin Klein, Allison N. Bucsan, Patricia A. Darrah, Robert A. Seder, Mario Roederer, Philana Ling Lin, JoAnne L. Flynn, Shelby L. O’Connor, Charles A. Scanga
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $11,690
Funders: U.S. Department of Health and Human Services, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, University of Pittsburgh, National Institutes of Health, NIH Office of the Director, National Institute of Allergy and Infectious Diseases, National Center for Research Resources
Awards: G2833012269, G4130047981, G4938866319, The Impact of Pre-exisiting SIV on Host Immunity to M tuberculosis in Macaques, G5936413717, G6937410429, G7069220706, G7578466963, G8355781796, Re-educating T cell-mediated immunity in SIV by modulating metabolic pathways, G8768721097, Wisconsin National Primate Research Center Support, Pitt RBL, Wisconsin National Primate Research Center Support
OpenAlex ID: W4387451803