Year: 2023
Type: review
Abstract: microRNAs (miRs) have been reported over the decades as important regulators in bone development and bone regeneration. They play important roles in maintaining the stem cell signature as well as regulating stem cell fate decisions. Thus, delivering miRs and miR inhibitors to the defect site is a potential treatment towards craniofacial bone defects. However, there are challenges in translation of basic research to clinics, including the efficiency, specificity, and efficacy of miR manipulation methods and the safety of miR delivery systems. In this review, we will compare miR oligonucleotides, mimics and antagomirs as therapeutic reagents to treat disease and regenerate tissues. Newer technology will be discussed as well as the efficiency and efficacy of using these technologies to express or inhibit miRs in treating and repairing oral tissues. Delivery of these molecules using extracellular vesicles and nanoparticles can achieve different results and depending on their composition will elicit specific effects. We will highlight the specificity, toxicity, stability, and effectiveness of several miR systems in regenerative medicine.
Source: Biochemical Society Transactions
DOI: 10.1042/bst20221448
Institutions: University of Iowa, Chiang Mai University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: Co-opting Lef-1 and miR-26b activities to regulate dental stem cells and their progeny, Oral and Craniofacial Bone Regeneration using MicroRNA Modulation, Hybrid 3D bioprinting of bone using microRNA-based bioink, New Biotechnology using MicroRNA Inhibitors to Regenerate Alveolar Bone, G9000152122, University of Iowa Institutional Training Program in Oral Health Research
OpenAlex ID: W4366352309