Ethyl Acetate Extract of Radix Cynanchi Auriculati Exerts Antioxidant Effects on LPS-induced RAW264.7 Cells by Regulating MAPKs/Nrf2/HO-1 Pathways
Year: 2023
Type: article
Abstract: Extracts of Radix Cynanchi Auriculati (RCA) have multiple effects. However, it remains unclear whether RCA extracts can exhibit antioxidant activity by regulating MAPKs/Nrf2/HO-1 pathways. In this study, we evaluated the antioxidant activity of ethyl acetate extract of RCA (RCAEA) via LPS-induced RAW264.7 cells, and investigated the potential mechanism of its protective effect against oxidative damage on macrophages. The results showed that RCAEA activating MAPKs/Nrf2/HO-1 pathways. In conclusion, the aim of this study was to describe the molecular mechanisms responsible for the RCAEA mediating the inhibitory effects of oxidative stress in RAW264.7 cells.
Authors: Jie Ren, Ya Su, Lili Zeng, Jichao Zhou, Siqi Yi, Yi Xing, Kun Hu
Institution: Changzhou University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Funder: Government of Jiangsu Province
OpenAlex ID: W4366779908