Meniscal degeneration is prognostic of destabilzing meniscal tear and accelerated knee osteoarthritis: Data from the Osteoarthritis Initiative
Year: 2023
Type: article
Abstract: The objective of this study was to assess the prognostic potential of magnetic resonance (MR)-detected meniscal degeneration in relation to incident destabilizing meniscal tears (radial, complex, root, or macerated) or accelerated knee osteoarthritis (AKOA). We used existing MR data from a case-control study of three groups from the Osteoarthritis Initiative without radiographic KOA at baseline: AKOA, typical KOA, and no KOA. From these groups, we included people without medial and lateral meniscal tear at baseline (n = 226) and 48-month meniscal data (n = 221). Intermediate-weighted fat-suppressed MR images annually from baseline to the 48-month visit were graded using a semiquantitative meniscal tear classification criterion. Incident destabilizing meniscal tear was defined as progressing from an intact meniscus to a destabilizing tear by the 48-month visit. We used two logistic regression models to assess whether: (1) presence of medial meniscal degeneration was associated with an incident medial destabilizing meniscal tear, and (2) presence of meniscal degeneration in either meniscus was associated with incident AKOA over the next 4 years. People with the presence of a medial meniscal degeneration had three times the odds of developing an incident destabilizing medial meniscal tear within 4 years compared with a person without medial meniscus degeneration (odds ratio [OR]: 3.03; 95% confidence interval [CI]: 1.40-6.59). People with meniscal degeneration had five times the odds of developing incident AKOA within 4 years compared with a person without meniscal degeneration in either meniscus (OR: 5.04; 95% CI: 2.57-9.89). Meniscal degeneration on MR is clinically meaningful as it relates to future poor outcomes.
Source: Journal of Orthopaedic Research®
DOI: 10.1002/jor.25575
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,750
Funders: U.S. Department of Health and Human Services, U.S. Department of Veterans Affairs, Pfizer, GlaxoSmithKline, Health Services Research and Development, Novartis Pharmaceuticals Corporation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1048107671, G1143620864, G1158108047, G1256772101, G166592988, G2381209221, G2482665851, Clinical Centers for the Osteoarthritis Initiative, G3049869442, G3429939743, G409491633, Metabolites of Dietary Intake and Risk of Knee Osteoarthritis, Data Coordinating Center for the Osteoarthritis Initiative, G482432850, Clinical Centers for the Osteoarthritis Initiative, G5672476635, G5716223526, G581468509, G604760239, G6470355408, G659721583, G724008290, Characterization of Rapidly Progressive Knee Osteoarthritis, Clinical Centers for the Osteoarthritis Initiative^Rhode Island, G8234285353, G8602293357, Clinical Centers for the Osteoarthritis Initiative, G897039181, Walk this Way: Physical Activity and Walking Biomechanics Lead to Early Knee OA Symptoms and Ultrasound-Detected Structural Pathology after ACL Reconstruction
OpenAlex ID: W4366814115