Work

p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization

Year: 2023

Type: article

Abstract: The major lysophospholipid component in oxidized LDL, lysophosphatidylcholine (lysoPC), can activate p38 MAP kinase, which in turn promotes externalization of Orai3 and STIM1-Orai3 association, suggesting involvement of arachidonic acid-regulated calcium (ARC) channels. The subsequent increase in intracellular calcium activates an Src kinase required for TRPC6 externalization. TRPC6 activation, which has been shown to inhibit endothelial cell migration, is blocked by p38 MAP kinase or Orai3 downregulation, and this partially preserves endothelial migration in lysoPC.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00425.2022

Authors: Pinaki Chaudhuri, Priya Putta, Michael A. Rosenbaum, Linda M. Graham

Institutions: Cleveland Clinic, Louis Stokes Cleveland VA Medical Center

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Heart, Lung, and Blood Institute