Work

Cyproheptadine Treatment of COVID-19-Induced Enteritis: Implications for Hyperinflammatory Phase Management

Year: 2023

Type: article

Abstract: ABSTRACT A patient presented with COVID-19-induced enteritis and colitis associated with a high D-dimer. Serotonin released by activated platelets can lead to inflammation and multiorgan failure in COVID-19 infection. Cyproheptadine blocks serotonin receptors. In light of a prior report that showed that cyproheptadine successfully treated neurologic sequelae in COVID-19, we applied this treatment to this patient. Rapid clinical improvement and reduction of D-dimer occurred after 3 doses of cyproheptadine. This inexpensive, well-tolerated, oral medication may be applicable to treat hyperinflammatory sequelae of COVID-19 infection.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001034

Authors: Leonard B. Weinstock, Angela M. Reiersen, Anshu Jain, Katerina Konstantinoff, William James, Farid Jalali

Institutions: Washington University in St. Louis, Missouri Baptist Medical Center, Washington University Medical Center

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4366977571

FWCI: 0.373

Cites: 20

Cited by: 2

Related to: 10