Work

COVID-19 Antigen Results Correlate with the Quantity of Replication-Competent SARS-CoV-2 in a Cross-Sectional Study of Ambulatory Adults during the Delta Wave

Year: 2023

Type: article

Study design: Observational Study

Abstract: Do rapid antigen test results correlate with replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (i.e., infectious) virus? In this cross-sectional diagnostic study of 626 adults, the sensitivity of the antigen test to identify replication-competent SARS-CoV-2 was 63.6% in asymptomatic and 91.0% in symptomatic participants. Viral culture titers were the highest at the onset of symptoms and rapidly declined by 7 days after symptom onset.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.00064-23

Authors: Yuan-Po Tu, Christopher Green, Linhui Hao, Alexander L. Greninger, Jennifer F. Morton, Heather A. Sights, Michael Gale, Paul K. Drain

Institution: University of Washington

Language: English

Topic: SARS-CoV-2 detection and testing

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Bill and Melinda Gates Foundation, Abbott Laboratories, Pfizer, Gilead Sciences, Novavax, National Institutes of Health, Abbott Diagnostics, National Institute of Allergy and Infectious Diseases, Common Fund

Awards: University of Washington Arboviral Research Network (UWARN), G1636177350, University of Washington Foundation - to develop and assess novel diagnostic tests for SARS-CoV-2, which may be useful in both the developed world as well as in low- and middle-income c..., G5316515788, G5514976981, G6784209815, G8424743005, G9000346859, Washington National Primate Research Center

OpenAlex ID: W4366991828

FWCI: 0.828

Cites: 20

Cited by: 4

Related to: 10