Work

Disulfidptosis: a new target for metabolic cancer therapy

Year: 2023

Type: article

Abstract: Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy. A recent study has identified a new metabolic-related RCD known as disulfidptosis. Preclinical findings suggest that metabolic therapy using glucose transporter (GLUT) inhibitors can trigger disulfidptosis and inhibit cancer growth. In this review, we summarize the specific mechanisms underlying disulfidptosis and outline potential future research directions. We also discuss the challenges that may arise in the clinical translation of disulfidptosis research.

Source: Journal of Experimental & Clinical Cancer Research

DOI: 10.1186/s13046-023-02675-4

Authors: Peijie Zheng, Chuntao Zhou, Yuemin Ding, Shiwei Duan

Institution: Hangzhou City University

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490