Correlation of serum interleukin-33 with HBV DNA load and ALT level in patients with chronic hepatitis B
Year: 2015
Type: article
Study design: Observational Study
Abstract: ObjectiveTo investigate the serum interleukin-33 (IL-33) level in patients with chronic hepatitis B, and to explore the correlation of serum IL-33 with hepatitis B virus (HBV) DNA load and alanine aminotransferase (ALT) level. MethodsA total of 119 patients with chronic hepatitis B and 131 healthy controls were enrolled in this study. Serum levels of IL-33 were determined by enzyme-linked immunosorbent assay. For patients with chronic hepatitis B, HBV DNA loads were quantified by real-time quantitative PCR, while ALT levels were measured by continuous monitoring assays. The t test was applied in the comparison of continuous data. The Pearson correlation analysis was used to investigate the correlation of serum IL-33 level with HBV DNA load and ALT level. ResultsSerum levels of IL-33 were significantly higher in patients with chronic hepatitis B (62.7±29.3 ng/ml) than in healthy controls (16.4±4.5 ng/ml) (t=17.02, P＜0.01). Serum IL-33 level was negatively correlated with log10 ［HBV DNA］(r=-0.703, P＜0.01) but positively correlated with ALT (r=0.324, P＜0.01) in patients with chronic hepatitis B. ConclusionThis study suggests that IL-33, an immune stimulator, may play a role in inhibiting HBV replication in patients with chronic hepatitis B.
Author: LU Ying
Institutions: Shanghai Jiao Tong University, Ruijin Hospital
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4367171434