Nutritional Blood Concentration Biomarkers in the Hispanic Community Health Study/Study of Latinos: Measurement Characteristics and Power
Year: 2023
Type: article
Abstract: Measurement error is a major issue in self-reported diet that can distort diet-disease relationships. Use of blood concentration biomarkers has the potential to mitigate the subjective bias inherent in self-reporting. As part of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) baseline visit (2008-2011), self-reported information on diet was collected from all participants (n = 16,415). The HCHS/SOL also included annual telephone follow-up, as well as a second (2014-2017) and third (2020-2023) clinic visit. Blood concentration biomarkers for carotenoids, tocopherols, retinol, vitamin B12, and folate were measured in a subset of participants (n = 476) as part of the Study of Latinos: Nutrition and Physical Activity Assessment Study (SOLNAS) (2010-2012). We examined the relationships among biomarker levels, self-reported intake, Hispanic/Latino background (Central American, Cuban, Dominican, Mexican, Puerto Rican, or South American), and other participant characteristics in this diverse cohort. We built regression calibration-based prediction equations for 10 nutritional biomarkers and used a simulation to study the power of detecting a diet-disease association in a multivariable Cox model using a predicted concentration level. Good statistical power was observed for some nutrients with high prediction model R2 values, but further research is needed to understand how best to realize the potential of these dietary biomarkers. This study provides a comprehensive examination of several nutritional biomarkers within the HCHS/SOL, characterizing their associations with subject characteristics and the influence of the measurement characteristics on the power to detect associations with health outcomes.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwad109
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Office of Dietary Supplements, Kaiser Permanente, University of Miami, University of Pennsylvania, Northwestern University, San Diego State University, University of Minnesota, Loyola University Chicago, Kaiser Permanente Washington Health Research Institute, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, University of North Carolina at Chapel Hill, Perelman School of Medicine, University of Pennsylvania, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center on Minority Health and Health Disparities, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1081972346, G1312369436, Hispanic Community Health Study, G1455175283, G1587824183, G1666450717, G1866572497, G1917633662, G1933508692, G2031372691, G2135211244, G2135293100, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2970637568, G3062787641, Hispanic Community Health Study, G3677686024, G3838006641, G4165985951, Hispanic Community Health Study, G4438318499, G4552920371, Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS), G4860668542, G4989378220, Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer Disease Risk, G528357465, G5365244667, Statistical methods for correlated outcome and covariate errors in studies of HIV/AIDS, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G555858244, G569253488, G5739677117, G5878028785, G5906656038, G5935820280, G6075306088, Clinical and Translational Science Award, G6156511736, G6585687856, G6744188800, G7057037114, G7203655167, G7239480477, G7278742613, G740393302, G7513901258, G7678550560, G8102260223, G820454163, G8386326007, G8811247504, G8840902395, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W4367296975