Year: 2023
Type: article
Abstract: Patients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1–2 years before diagnosis that can result in changes to medications. We investigate recent medication changes and PDAC diagnosis in Nurses’ Health Study (NHS; females) and Health Professionals Follow-up Study (HPFS; males), including up to 148,973 U.S. participants followed for 2,994,057 person-years and 991 incident PDAC cases. Here we show recent initiation of antidiabetic (NHS) or anticoagulant (NHS, HFS) medications and cessation of antihypertensive medications (NHS, HPFS) are associated with pancreatic cancer diagnosis in the next 2 years. Two-year PDAC risk increases as number of relevant medication changes increases ( P -trend <1 × 10 −5 ), with participants who recently start antidiabetic and stop antihypertensive medications having multivariable-adjusted hazard ratio of 4.86 (95%CI, 1.74–13.6). These changes are not associated with diagnosis of other digestive system cancers. Recent medication changes should be considered as candidate features in multi-factor risk models for PDAC, though they are not causally implicated in development of PDAC.
Source: Nature Communications
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,290
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1160275816, G1416987869, G1889983372, G2214254730, G2750880407, G294025628, G3754462075, Dietary and Hormonal Determinants of Cancer in Women, G4376790518, G4526125921, Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts, G547275475, G6200764915, Integrative approaches to identify novel markers for early detection of pancreatic cancer, G6682102338, G6719391877, G6780254327, G7376971866, G885693336, G9000000635, G9000043058, G9000058679, G9000099730, G9000122174, G9000157792, G9000190097, Leveraging Novel Randomized Clinical Trials of Vitamin D Supplementation in Patients with Colorectal Cancer: Impact on Survival and Anti-Tumor Immunity, Altered metabolism and machine learning for pancreatic cancer early detection
OpenAlex ID: W4367300347