Work

Amino acid metabolism, redox balance and epigenetic regulation in cancer

Year: 2023

Type: review

Abstract: Amino acids act as versatile nutrients driving cell growth and survival, especially in cancer cells. Amino acid metabolism comprises numerous metabolic networks and is closely linked with intracellular redox balance and epigenetic regulation. Reprogrammed amino acid metabolism has been recognized as a ubiquitous feature in tumour cells. This review outlines the metabolism of several primary amino acids in cancer cells and highlights the pivotal role of amino acid metabolism in sustaining redox homeostasis and regulating epigenetic modification in response to oxidative and genetic stress in cancer cells.

Source: FEBS Journal

DOI: 10.1111/febs.16803

Authors: Xiang Li, Hong‐Sheng Zhang

Institution: Beijing University of Technology

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Natural Science Foundation of Beijing Municipality, National Laboratory of Biomacromolecules