The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
Year: 2023
Type: article
Abstract: BACKGROUND: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. METHODS: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. RESULTS: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). CONCLUSIONS: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
Source: Brain Behavior and Immunity
Authors: Ruihua Hou, Gang Ye, Xiaojing Cheng, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlen, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Charles Auffray, Bertrand De Meulder, Ana R. Sousa, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Paul J. Skipp, James Schofield, Ratko Djukanović
Institutions: University of Southampton, Suzhou Guangji Hospital, Shandong Mental Health Center, University of Nottingham, University of Bergen, University of Catania, Karolinska Institutet, Manchester Academic Health Science Centre, University of Manchester, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Semmelweis University, Fraunhofer Institute for Toxicology and Experimental Medicine, Università Cattolica del Sacro Cuore, Jagiellonian University, Umeå University, Lyon 1 Université, Centre National de la Recherche Scientifique, Inserm, Université de Lyon, GlaxoSmithKline (United Kingdom), Imperial College London, Amsterdam University Medical Centers, University of Amsterdam, NIHR Southampton Respiratory Biomedical Research Unit, NIHR Southampton Biomedical Research Centre
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Funders: Amgen, AstraZeneca, Chiesi Farmaceutici, Uniwersytet Jagielloński Collegium Medicum, University Hospital Southampton NHS Foundation Trust, Royal Brompton and Harefield NHS Foundation Trust, National Institute for Health and Care Research, Asthma and Lung UK, University of Southampton, Imperial College London, Universiteit van Amsterdam, Semmelweis Egyetem, Gentofte Hospital, Karolinska Institutet, Kungliga Tekniska Högskolan, Università di Catania, Universitetet i Bergen, Uppsala Universitet, Wessex Medical Research, Science for Life Laboratory, Université de Lyon, Genentech, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council
Awards: G303163932, G7863499981
OpenAlex ID: W4367839784