Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview

Year: 2023

Type: article

Abstract: Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex- and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comorbidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD: n = 550,748; no ADHD n = 14,546,814) yielded pooled odds ratios of 5.0(CI:3.29-7.46) for ADs, 4.5(CI:2.44-8.34) for MDD, 8.7(CI:5.47-13.89) for BD and 4.6(CI:2.72-7.80) for SUDs, indicating strong differences in adults with compared to adults without ADHD. Moderation by sex was not found: high comorbidity held for both men and women with sex-specific patterns as in the general population: higher prevalences of ADs, MDD and BD in women and a higher prevalence of SUDs in men. Insufficient data on different phases of the adult lifespan prevented conclusions on developmental changes in comorbidity. We discuss methodological challenges, knowledge gaps, and future research priorities.

Source: Neuroscience & Biobehavioral Reviews

DOI: 10.1016/j.neubiorev.2023.105209

Authors: Catharina A. Hartman, Henrik Larsson, Melissa Vos, Alessio Bellato, Berit Libutzki, Berit Skretting Solberg, Qi Chen, Ebba Du Rietz, Jeanette C. Mostert, Sarah Kittel-Schneider, Bru Cormand, Marta Ribasés, Kari Klungsøyr, Jan Haavik, Søren Dalsgaard, Samuele Cortese, Stephen V. Faraone, Andreas Reif

Institutions: University Medical Center Groningen, University of Groningen, Örebro University, Karolinska Institutet, University of Nottingham Malaysia Campus, Betanien Hospital, University of Bergen, Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Universitätsklinikum Würzburg, Instituto de Salud Carlos III, Centre for Biomedical Network Research on Rare Diseases, Institut de Recerca Sant Joan de Déu, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Norwegian Institute of Public Health, Haukeland University Hospital, Aarhus University, Lundbeck Foundation, University of Nottingham, Solent NHS Trust, NYU Langone Health, University of Southampton, New York University, SUNY Upstate Medical University, Goethe University Frankfurt, University Hospital Frankfurt

Language: English

Topic: Attention Deficit Hyperactivity Disorder

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,720

Funders: Fundació la Marató de TV3, Ministerio de Ciencia, Innovación y Universidades, European Commission, Generalitat de Catalunya, Institució Catalana de Recerca i Estudis Avançats, European College of Neuropsychopharmacology, Horizon 2020 Framework Programme, Agència de Gestió d'Ajuts Universitaris i de Recerca, National Institute of Mental Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

OpenAlex ID: W4368348134