Effet de la prise orale de glutamine sur la fonction et la masse musculaire dans la dystrophie de Duchenne de Boulogne
Year: 2008
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background:Glutaminehas been shown to acutely decreasewhole- body protein degradation in Duchenne muscular dystrophy (DMD). Objective: To improve nutritional support in DMD, we tested whether oral supplementation with glutamine for 10 d decreased whole-body protein degradation significantly more than did an iso- nitrogenous amino acid control mixture. Design: Twenty-six boys with DMDwere included in this random- ized, double-blind parallel study; they received an oral supplement of either glutamine (0.5 g · kg 1 · d ) or an isonitrogenous, non- specific amino acidmixture (0.8 g · kg 1 · d ) for 10 d. The subjects in each group were not clinically different at entry. Leucine and glutaminemetabolismswere estimated in the postabsorptive state by using a primed continuous intravenous infusion of [1-C]leucine and [2-N]glutamine before and 10 d after supplementation. Results: A significant effect of time was observed on estimates of whole-body protein degradation. A significant (P 0.05) decrease in the rate of leucine appearance (an index of whole-body protein degradation) was observed after both glutamine and isonitrogenous amino acid supplementation [x SEM: 136 9 to 124 6 mol · kg fat-free mass (FFM) 1 · h 1 for glutamine and 136 6 to 131 8 mol · kg FFM 1 · h 1 for amino acids]. A significant (P 0.05) decrease in endogenous glutamine due to protein breakdown was alsoobserved (91 6 to83 4 mol · kgFFM 1 · h 1 for glutamine and 91 4 to 88 5 mol · kg FFM 1 · h 1 for amino acids). The decrease in the estimates of whole-body protein degradation did not differ significantly between the 2 supplemental groups. Conclusion:Oral glutamine or amino acid supplementation over 10 d equally inhibits whole-body protein degradation in DMD. Am J Clin Nutr 2006;83:823–8.
Author: Élise Mok
Language: French
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W436900978