Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Work
Year: 2023
Type: article
Abstract: The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and appl... more
Source: Nature Communications
Institutions The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, New York University, Institute of Biophysics, Chinese Academy of Sciences +1 more
Cites: 94
Cited by: 34
Related to: 10
FWCI: 8.293
Citation percentile (by year/subfield): 99.99
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Sustainable Development Goal Reduced inequalities
Open Access status: gold
APC paid (est): $4,808