Plasmodium vivax infection alters the peripheral immunoregulatory network of CD4 T follicular cells and B cells
Year: 2023
Type: article
Study design: Observational Study
Abstract: Regulatory and effector cell responses to Plasmodium vivax, the most common human malaria parasite outside Africa, remain understudied in naturally infected populations. Here, we describe peripheral CD4+ T‐ and B‐cell populations during and shortly after an uncomplicated P. vivax infection in 38 continuously exposed adult Amazonians. Consistent with previous observations, we found an increased frequency in CD4+CD45RA−CD25+FoxP3+ T regulatory cells that express the inhibitory molecule CTLA‐4 during the acute infection, with a sustained expansion of CD21−CD27− atypical memory cells within the CD19+ B‐cell compartment. Both Th1‐ and Th2‐type subsets of CXCR5+ICOShiPD‐1+ circulating T follicular helper (cTfh) cells, which are thought to contribute to antibody production, were induced during P. vivax infection, with a positive correlation between overall cTfh cell frequency and IgG antibody titers to the P. vivax blood‐stage antigen MSP119. We identified significant changes in cell populations that had not been described in human malaria, such as an increased frequency of CTLA‐4+ T follicular regulatory cells that antagonize Tfh cells, and a decreased frequency of circulating CD24hiCD27+ B regulatory cells in response to acute infection. In conclusion, we disclose a complex immunoregulatory network that is critical to understand how naturally acquired immunity develops in P. vivax malaria.
Source: European Journal of Immunology
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Science Foundation, Universidade Federal do Acre, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Awards: Influence of STAT1, STAT3, STAT5 and STAT6 Signaling Pathways on Conventional Dendritic Cells in the Instruction of the T-Cell Auxiliary Response, G1207375514, Amazonian Center of Excellence in Malaria Research, Sero-surveillance tools for targeting Plasmodium vivax infections and monitoring malaria control and elimination efforts in Amazonian countries, Scientific bases for residual malaria elimination in the Brazilian Amazon, G6528704105
OpenAlex ID: W4376108306