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Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways

Year: 2023
Type: article
Abstract: BACKGROUND: Hepatic fibrosis is a serious condition, and the development of hepatic fibrosis can lead to a series of complications. However, the pathogenesis of hepatic fibrosis remains unclear, and effective therapy options are still lacking. Our group identified hepatitis C virus nonstructural protein 3-transactivated protein 1 (NS3TP1) by suppressive subtractive hybridization and bioinformatics analysis, but its role in diseases including hepatic fibrosis remains undefined. Therefore, additional studies on the function of NS3TP1 in hepatic fibrosis are urgently needed to provide new targets for treatment. AIM: To elucidate the mechanism of NS3TP1 in hepatic fibrosis and the regulatory effects of calcitriol on NS3TP1. METHODS: test. RESULTS: downregulation of NS3TP1. CONCLUSION: Our results suggest that calcitriol may be employed as an adjuvant therapy for hepatic fibrosis and that NS3TP1 is a unique, prospective therapeutic target in hepatic fibrosis.
DOI: 10.3748/wjg.v29.i18.2798
Authors: Liu Shi, Li Zhou, Ming Han, Yu Zhang, Yang Zhang, Xiao-Xue Yuan, Hong-Ping Lu, Yun Wang, Xue-Liang Yang, Chen Liu, Jun Wang, Pu Liang, Shun-Ai Liu, Xiao-Jing Liu, Jun Cheng, Shu-Mei Lin
Institutions: First Affiliated Hospital of Xi'an Jiaotong University, First Hospital of Xi'an, Xi'an Jiaotong University, China-Japan Friendship Hospital, Capital Medical University, Beijing Ditan Hospital, Peking University
Language: English
Subfield: Hepatology
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4376119940
FWCI: 1.515
Cites: 37
Cited by: 9
Related to: 10