Work

Role of ALOX5 in non-small cell lung cancer: A potential therapeutic target associated with immune cell infiltration.

Year: 2023

Type: article

Abstract: OBJECTIVES: The efficacy of immunotherapy for lung cancer is closely related to immune cell infiltration. Arachidonic acid 5-lipoxygenase (ALOX5) can activate inflammatory responses and trigger various cell death patterns; however, the relevance of ALOX5 to immune cell infiltration in lung cancer is unclear. The expression of ALOX5 in non-small cell lung cancer (NSCLC) is analyzed using an online database to explore the correlation between ALOX5 and immune cell infiltration in NSCLC and its relationship with prognosis. METHODS: may be involved in; and the TIMER database was used to analyze the effect of ALOX5 expression on the level of immune cell infiltration. RESULTS: <0.001). CONCLUSIONS: gene may be a potential biomarker of NSCLC prognosis associated with immune cell infiltration.

Source: PubMed Central

DOI: 10.11817/j.issn.1672-7347.2023.220427

Authors: Qianqian Zhao, Zhi Sun, Yuemei Pan, Qi Jing, Wei Li, Chuanxi Wang

Institutions: Shandong University, Shandong Provincial Hospital

Language: English

Topic: Lung Cancer Research Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Central South University, Natural Science Foundation of Shandong Province