Year: 2023
Type: article
Study design: Case Report
Abstract: A 20-year-old man diagnosed with urticaria pigmentosa at age 2 presented with rising tryptase levels (89.2 ng/mL [normal < 11.5 ng/mL]) and increased episodes of flushing.Complete blood count results were within normal limits.A bone marrow evaluation was performed.The aspirate smear demonstrated increased mature appearing, round, and well-granulated mast cells (panel A, Wright-Giemsa stain, ×100 objective, ×1000 total magnification).The core biopsy showed normocellular marrow with multiple large aggregates of round mast cells (panel B, hematoxylin and eosin [H&E] stain, ×20 objective, ×200 total magnification; and panel C, H&E, ×100 objective, ×1000 total magnification).By immunohistochemistry, the mast cells were positive for tryptase (panel D; ×100 objective, ×1000 total magnification), CD30 (panel E; ×100 objective, ×1000 total magnification), and variable CD25 in minor subset (panel
Source: Blood
Authors: Nisha Patel, Irina Maric
Institution: National Institutes of Health
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4376132671