Weight gain on dolutegravir: Association is not the same as causation
Year: 2023
Type: editorial
Abstract: Dolutegravir and other integrase strand transfer inhibitors are associated with more weight gain in people starting antiretroviral therapy (ART) than other antiretroviral drug classes.1,2 Antiretroviral therapy-naïve people gain weight after starting ART, irrespective of whether the regimen includes dolutegravir -this is a return-to-health phenomenon.Weight gain is most marked if ART is started with CD4 counts below 200 cells/µL.1 Women gain more weight after starting ART than men. 1 The South African ADVANCE study reported more weight gain in participants randomised to dolutegravir than efavirenz, which was more marked among women.3 This observation has caused concern because women in sub-Saharan Africa have a higher prevalence of both HIV and obesity than men. 4
Institutions: University of Cape Town, University of the Witwatersrand
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $605
OpenAlex ID: W4376137709