Dedifferentiated cells obtained from glioblastoma cell lines are an easy and robust model for mesenchymal glioblastoma stem cells studies.
Year: 2023
Type: article
Abstract: , integrin α5). Dedifferentiated GSC were similar to BTIC in terms of size and heterogeneity. The characterization study also revealed that CXCR4 pathway was activated by dedifferentiation, emphasizing its role as a potential therapeutic target. The expression of resistance-associated markers and the phenotypic diversity of the 4 GSC models obtained by dedifferentiation make them relevant to challenge future GSC targeting therapies.
Source: PubMed Central
Institutions: Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire d'Angers, Micro et Nanomédecines translationnelles, Université d'Angers, Mitochondrial and Cardiovascular Physiopathology, Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers, Nantes Université
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Ligue Contre le Cancer
OpenAlex ID: W4376225783