Year: 2023
Type: review
Abstract: Dendritic cells (DCs) are innate immune cells that detect and process environmental signals and communicate them with T cells to bridge innate and adaptive immunity. Immune signals and microenvironmental cues shape the function of DC subsets in different contexts, which is associated with reprogramming of cellular metabolic pathways. In addition to integrating these extracellular cues to meet bioenergetic and biosynthetic demands, cellular metabolism interplays with immune signaling to shape DC-dependent immune responses. Emerging evidence indicates that lipid metabolism serves as a key regulator of DC responses. Here, we summarize the roles of fatty acid and cholesterol metabolism, as well as selective metabolites, in orchestrating the functions of DCs. Specifically, we highlight how different lipid metabolic programs, including de novo fatty acid synthesis, fatty acid β oxidation, lipid storage, and cholesterol efflux, influence DC function in different contexts. Further, we discuss how dysregulation of lipid metabolism shapes DC intracellular signaling and contributes to the impaired DC function in the tumor microenvironment. Finally, we conclude with a discussion on key future directions for the regulation of DC biology by lipid metabolism. Insights into the connections between lipid metabolism and DC functional specialization may facilitate the development of new therapeutic strategies for human diseases.
Source: Immunological Reviews
DOI: 10.1111/imr.13215
Authors: Zhiyuan You, Hongbo Chi
Institution: St. Jude Children's Research Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: G1980380190, G4597687758, Nutrient sensing and lysosomal signaling in regulatory T cells and immune tolerance, G6247008096, G6328516692, G9000017361, G9000213926, G9000305082, Transcriptional and metabolic heterogeneity in T cell differentiation, Regulation of T cell memory in tissue immunity
OpenAlex ID: W4376254638