Hi-Fi fMRI: High-resolution, fast-sampled and sub-second whole-brain functional MRI at 3T in humans
Year: 2023
Type: preprint
Abstract: ABSTRACT Functional magnetic resonance imaging (fMRI) is a methodological cornerstone of neuroscience. Most studies measure blood-oxygen-level-dependent (BOLD) signal using echo-planar imaging (EPI), Cartesian sampling, and image reconstruction with a one-to-one correspondence between the number of acquired volumes and reconstructed images. However, EPI schemes are subject to trade-offs between spatial and temporal resolutions. We make strides in overcoming these limitations by measuring BOLD with a gradient recalled echo (GRE) with a 3D radial-spiral phyllotaxis trajectory at a high sampling rate (28.49ms) on standard 3T field strength. The framework enables the reconstruction of 3D signal time courses with whole-brain coverage at simultaneously higher nominal spatial (1mm 3 ) and temporal (up to 250ms) resolutions, as compared to optimized EPI schemes. Additionally, we apply motion correction directly to the k-space raw data, enabling flexible motion-corrected reconstructions; the desired temporal resolution to observe hemodynamic responses can be chosen after scanning. By showing activation in the calcarine sulcus of 20 participants completing an ON-OFF visual paradigm, we demonstrate the reliability of our method for applications in cognitive neuroscience research.
Authors: Benedetta Franceschiello, Simone Rumac, Mauro Leidi, Tom Hilbert, Matthias Nau, Martyna Dziadosz, Giulio Degano, Christopher W. Roy, Anna Gaglianese, Giovanni Petri, Jérôme Yerly, Matthias Stuber, Tobias Kober, Ruud B. van Heeswijk, Jessica A.M. Bastiaansen, João Jorge, Micah M. Murray, Eleonora Fornari
Institutions: HES-SO University of Applied Sciences and Arts Western Switzerland, Centre Hospitalier Universitaire Vaudois, HES-SO Valais-Wallis, Centre d'Imagerie BioMedicale, The Sense Innovation and Research Center, University of Lausanne, National Institutes of Health, National Institute of Mental Health, École Polytechnique Fédérale de Lausanne, University of Geneva, University of Bern, University Hospital of Bern, Swiss Center for Electronics and Microtechnology (Switzerland)
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: A Paradigm Shift in Magnetic Resonance Imaging of the Heart: 5D Imaging - Sample Now and Ask Questions Later, Non-invasive and Regional 3D Measures of Coronary Vasomotor Function, Delayed Hyperenhancement and Vessel Wall Plaque Characteristics in Early Atherosclerosis Using Advanced High-Field Magnetic Resonance Imaging, Development of Advanced Translational High-Field MRI, A high-resolution, sub-second and fast-sampled resting state fMRI protocol for a better disentangling of neural, hemodynamic, physiological and movement activity in BOLD signal, Core multisensory mechanisms: Closing in on real-world functions, 2.0 MR-EYE Towards a consensual Magnetic resonance Imaging protocol of the Human Eye, Object, face, body and scene representations in the human brain
OpenAlex ID: W4376603780