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Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Year: 2023
Type: article
Abstract: The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.
DOI: 10.3390/ijms24108805
Authors: Zufeng Wang, Chengliang Luo, Edward W. Zhou, Aaron F. Sandhu, Xiaojing Yuan, George E. Williams, Jialu Cheng, Bharati Sinha, Mohammed Akbar, Pallab Bhattacharya, Shuanhu Zhou, Byoung-Joon Song, Xin Wang
Institutions: Brigham and Women's Hospital, Harvard University, Soochow University, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Pharmaceutical Education and Research - Ahmedabad, Harvard Stem Cell Institute
Language: English
Field: Psychology
Open Access status: gold
Estimated APC paid: $2,780
OpenAlex ID: W4376645218
FWCI: 2.705
Cites: 180
Cited by: 10
Related to: 10