Work

From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Year: 2023

Type: article

Abstract: identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2023.101039

Authors: Y. David Seo, Jennifer A. Wargo

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,460