Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection
Year: 2023
Type: article
Abstract: OBJECTIVE: The perturbation of tryptophan (TRP) metabolism has been linked with HIV infection and cardiovascular disease (CVD), but the interrelationship among TRP metabolites, gut microbiota, and atherosclerosis remain unclear in the context of HIV infection. METHODS: We included 361 women (241 HIV+, 120 HIV-) with carotid artery plaque assessments from the Women's Interagency HIV Study, measured 10 plasma TRP metabolites and profiled fecal gut microbiome. TRP metabolite-related gut bacteria were selected through the Analysis of Compositions of Microbiomes with Bias Correction method. Associations of TRP metabolites and related microbial features with plaque were examined using multivariable logistic regression. RESULTS: Although plasma kynurenic acid (KYNA) [odds ratio (OR) = 1.93, 95% confidence interval (CI): 1.12-3.32 per one SD increase; P = 0.02) and KYNA/TRP [OR = 1.83 (95% CI 1.08-3.09), P = 0.02] were positively associated with plaque, indole-3-propionate (IPA) [OR = 0.62 (95% CI 0.40-0.98), P = 0.03] and IPA/KYNA [OR = 0.51 (95% CI 0.33-0.80), P < 0.01] were inversely associated with plaque. Five gut bacterial genera and many affiliated species were positively associated with IPA (FDR-q < 0.25), including Roseburia spp ., Eubacterium spp., Lachnospira spp., and Coprobacter spp.; but no bacterial genera were found to be associated with KYNA. Furthermore, an IPA-associated-bacteria score was inversely associated with plaque [OR = 0.47 (95% CI 0.28-0.79), P < 0.01]. But no significant effect modification by HIV serostatus was observed in these associations. CONCLUSION: In a cohort of women living with and without HIV infection, plasma IPA levels and related gut bacteria were inversely associated with carotid artery plaque, suggesting a potential beneficial role of IPA and its gut bacterial producers in atherosclerosis and CVD.
Source: AIDS
Authors: Kai Luo, Zheng Wang, Brandilyn A. Peters, David B. Hanna, Tao Wang, Christopher C. Sollecito, Evan Grassi, Fanua Wiek, Lauren St. Peter, Mykhaylo Usyk, Wendy S. Post, Alan L. Landay, Howard N. Hodis, Kathleen M. Weber, Audrey French, Elizabeth F. Topper, Jason Lazar, Deborah Gustafson, Anjali Sharma, Kathryn Anastos, Clary B. Clish, Rob Knight, Robert C. Kaplan, Robert D. Burk, Qibin Qi
Institutions: Albert Einstein College of Medicine, Johns Hopkins University, Rush University Medical Center, University of Southern California, Hektoen Institute, SUNY Downstate Health Sciences University, State University of New York, Broad Institute, University of California San Diego, Fred Hutch Cancer Center, Harvard University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: City University of New York, Northwestern University, Feldstein Medical Foundation, National Institutes of Health, Center for AIDS Research, University of Washington, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: Dietary Patterns and Risk of Cardiovascular Disease, Evaluation of HIV-associated Cardiac Dysfunction in Women, Inflammatory and Immune Mechanisms of Atherosclerosis in HIV-Infected Women, G4517903627, Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations, Epidemiology of the gut microbiome, prediabetes and diabetes in Latinos, Mechanisms of Atherosclerosis and CVD in HIV+ Women, G5147848267, Role of innate immunity in HIV related vascular disease: biomarkers & mechanisms, G5660189159, Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites, G5863844756, HIV Infection, Metabolites and Subclinical Atherosclerosis, Clinical and Translational Science Institute, Metabolomics signatures underlying diet, lifestyle and gut microbiota for diabetes, G6396423216, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G7152846654, Johns Hopkins Institute for Clinical and Translational Research, Women's Interagency HIV Study (WIHS-V), Multicenter AIDS Cohort Study - Part B (Baltimore Center), Prediction of heart failure in HIV-infected individuals, Multiomics analysis of the microbiome and subclinical cardiovascular disease in HIV infection, University of Pittsburgh MACS/WIHS CCS, MACS/WIHS -CCS, ERC Einstein-Rockefeller-CUNY Center for AIDS research, Cancer Center Support Grant, SF Bay Area MACS/WIHS Combined Cohort Study, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Center for AIDS Research at Emory University, Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults, Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research, Los Angeles CRS for the MACS/WIHS Combined Cohort Study, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study, MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS), The University of North Carolina Center for AIDS Research, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, Boston Area Nutrition Obesity Research Center (NORC), Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site, UAB-MISS MACS/WIHS Combined Cohort Study, Miami Center for AIDS Research, UCLA Clinical and Translational Science Institute, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4377011176