Prospective Longitudinal Perfusion in Probable Alzheimer’s Disease Correlated with Atrophy in Temporal Lobe
Year: 2023
Type: article
Abstract: Reduced cerebral blood flow (CBF) in the temporoparietal region and gray matter volumes (GMVs) in the temporal lobe were previously reported in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the temporal relationship between reductions in CBF and GMVs requires further investigation. This study sought to determine if reduced CBF is associated with reduced GMVs, or vice versa. Data came from 148 volunteers of the Cardiovascular Health Study Cognition Study (CHS-CS), including 58 normal controls (NC), 50 MCI, and 40 AD who had perfusion and structural MRIs during 2002-2003 (Time 2). Sixty-three of the 148 volunteers had follow-up perfusion and structural MRIs (Time 3). Forty out of the 63 volunteers received prior structural MRIs during 1997-1999 (Time 1). The relationships between GMVs and subsequent CBF changes, and between CBF and subsequent GMV changes were investigated. At Time 2, we observed smaller GMVs (p<0.05) in the temporal pole region in AD compared to NC and MCI. We also found associations between: (1) temporal pole GMVs at Time 2 and subsequent declines in CBF in this region (p=0.0014) and in the temporoparietal region (p=0.0032); (2) hippocampal GMVs at Time 2 and subsequent declines in CBF in the temporoparietal region (p=0.012); and (3) temporal pole CBF at Time 2 and subsequent changes in GMV in this region (p = 0.011). Therefore, hypoperfusion in the temporal pole may be an early event driving its atrophy. Perfusion declines in the temporoparietal and temporal pole follow atrophy in this temporal pole region.
Source: Aging and Disease
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
Funders: National Science Foundation, Washington University in St. Louis, University of Pittsburgh, National Institutes of Health, Binghamton University, Cancer Institute, University of Pittsburgh, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Division of Civil, Mechanical and Manufacturing Innovation
Awards: G1023702118, G1097528416, G125972088, G1261314546, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1401438683, G1438302022, CORONARY HEART DISEASE AND STROKE, G1726490033, Basal Forebrain connections to the heart and mind in healthy aging, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G2391884931, G2404385439, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G2899267414, G3045517347, G3137375862, G3220743633, G322252321, G34347772, CHS research resources for the cardiovascular health of older adults, G3727798245, G4219624527, G423252844, G4622379297, G4942589162, G5145575165, G544148272, G5490141068, G581887176, CHS Events Follow-up Study, G6226795708, G6551505877, CHS-Transition Phase, Mechanics of the Formation of Cortical Folding Patterns in the Developing Human Brain, G7176672723, G7217924807, Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife Obesity, In vivo insights of small vessel changes with age using USPIO-enhanced MRI, G766700449, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G806768229, Functional MRI in Schizophrenia, Mechanisms of age-related white matter hyperintensities: insights from advanced MRI, G905887895
OpenAlex ID: W4377011775