Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background Researchers have identified genetic and neural risk factors for externalizing behaviors. However, it has not yet been determined if genetic liability is conferred in part through associations with more proximal neurophysiological risk markers. Methods Participants from the Collaborative Study on the Genetics of Alcoholism, a large, family-based study of alcohol use disorders were genotyped and polygenic scores for externalizing (EXT PGS) were calculated. Associations with target P3 amplitude from a visual oddball task (P3) and broad endorsement of externalizing behaviors (indexed via self-report of alcohol and cannabis use, and antisocial behavior) were assessed in participants of European (EA; N = 2851) and African ancestry (AA; N = 1402). Analyses were also stratified by age (adolescents, age 12–17 and young adults, age 18–32). Results The EXT PGS was significantly associated with higher levels of externalizing behaviors among EA adolescents and young adults as well as AA young adults. P3 was inversely associated with externalizing behaviors among EA young adults. EXT PGS was not significantly associated with P3 amplitude and therefore, there was no evidence that P3 amplitude indirectly accounted for the association between EXT PGS and externalizing behaviors. Conclusions Both the EXT PGS and P3 amplitude were significantly associated with externalizing behaviors among EA young adults. However, these associations with externalizing behaviors appear to be independent of each other, suggesting that they may index different facets of externalizing.
Source: Psychological Medicine
Authors: Sarah J. Brislin, Jessica E. Salvatore, Jacquelyn M. Meyers, Chella Kamarajan, Martin H. Plawecki, Howard J. Edenberg, Samuel Kuperman, Jay Tischfield, Victor Hesselbrock, Andrey P. Anokhin, David B. Chorlian, Marc A. Schuckit, John I. Nurnberger, Lance Bauer, Gayathri Pandey, Ashwini K. Pandey, John R. Kramer, Grace Chan, Bernice Porjesz, COGA Collaborators, Danielle M. Dick
Institutions: Rutgers, The State University of New Jersey, State University of New York, SUNY Downstate Health Sciences University, Indiana University Bloomington, Indiana University, University of Iowa, University of Connecticut, UConn Health, Washington University in St. Louis, University of California San Diego
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,255
Funders: Children's Hospital of Philadelphia, University of Pennsylvania, State University of New York, Washington University in St. Louis, University of Connecticut, National Institutes of Health, SUNY Downstate Medical Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse
OpenAlex ID: W4377094571