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Editorial: Translational phenomics and its applications in immunotherapy

Year: 2023

Type: editorial

Abstract: Editorial on the Research Topic Translational phenomics and its applications in immunotherapyImmunotherapy has emerged as a promising treatment option for a variety of diseases, including cancer and immune-mediated disorders.Its success depends on identifying the right target, selecting the right patient population, monitoring host immune responses, and managing adverse effects.Coined by Steven Garan (1), the term "phenomics" (2) refers to all measurable micro-and macro-phenotypic manifestations beyond an individual's genome, including cellular senescence (3), the tumor microenviroment (4), metabolome (5), and gut microbiome (6), to name but a few.Deep phenotyping of the patient immune system and diseased tissues is essential to better understand disease pathogenesis, identify key diagnostic biomarkers, and develop rational therapeutics with favorable clinical outcomes (7-9).The Frontiers in Immunology Research Topic "Translational Phenomics and its Applications in Immunotherapy" has published cutting-edge articles that use systems thinking and phenomics strategy (8, 10), along with omics and 3D printing technologies, to address significant challenges in immunotherapy.This Editorial summarizes six original articles included in this Research Topic, which can be grouped under three umbrellas, namely, "cellular senescence and cancer immunotherapy", "rational treatments and diagnostic markers", and "omics strategies and 3D printing technologies". Cellular senescence and cancer immunotherapyUnlocking the power of cellular senescence-related genes: prognostic and therapeutic significance in clear cell renal cell carcinomaThis study conducted a comprehensive analysis of the significance of cellular senescencerelated genes in ccRCC and their impact on patient survival and treatment response (Lu et al.).By leveraging public databases, the authors identified three molecular subtypes of ccRCC with varying clinical manifestations, mutation patterns, and tumor Frontiers in Immunology frontiersin.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2023.1211704

Authors: Hai Fang, Liye Chen, Leroy Hood, Qiang Tian