Correction: LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries
Year: 2023
Type: erratum
Abstract: Background: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur.The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment.Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease.Nevertheless, large population-based studies with costeffectiveness analyses are still lacking to support the widespread use of such tools.The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease.Methods: This study aims to include 30,000 subjects from eight European countries.Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center.In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography.If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy.The primary outcome is the percentage of subjects with LSM ≥ 8kPa.In
Source: BMC Public Health
Authors: Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Guillem Pera, Céline Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Ginès
Institutions: Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of Southern Denmark, Odense University Hospital, University of Zurich, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer, Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Institut Català de la Salut, Erasmus MC, University of Zagreb, University Hospital Dubrava, Universitätsklinikum des Saarlandes, Université Sorbonne Paris Nord, Assistance Publique – Hôpitaux de Paris, Hôpital Avicenne, University Medical Center of the Johannes Gutenberg University Mainz, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, University of Padua, Azienda Ospedale - Università Padova, The Royal Free Hospital, University College London, Nottingham University Hospitals NHS Trust, University of Nottingham, Hospital Del Mar, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Echosens (France), University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Medizinische Hochschule Hannover, Barcelona Supercomputing Center, Mayo Clinic, Oslo University Hospital, Université Paris Cité, Hôpital Beaujon, Saarland University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,990
Funder: European Commission
OpenAlex ID: W4377238991