Work

Label-free detection of MiRNA biomarkers using broadband multi-resonant infrared metasurfaces for early breast cancer diagnosis

Year: 2023

Type: article

Abstract: Squared value of up to 0.98. This study represents the first use of a SEIRA sensor for biomarker detection on clinical breast cancer samples and introduces an analysis method that produces results comparable to industry standards. Our findings pave the way for routine cancer diagnosis in the future. Additionally, the method discussed can be generalized to other biosensing activities involving two-step binding processes with complementary molecule-capturing agents.

Source: Nanoscale

DOI: 10.1039/d3nr01369c

Authors: Shuyan Zhang, Qing Yang Steve Wu, Yi Fan Chen, Melissa Hum, Dave Chi Lok Wong, Ern Yu Tan, Ann Siew Gek Lee, Jinghua Teng, Dinish U.S, Malini Olivo

Institutions: Agency for Science, Technology and Research, Institute of Materials Research and Engineering, National Cancer Centre Singapore, Chang Gung University, Nanyang Technological University, Tan Tock Seng Hospital

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Agency for Science, Technology and Research, Medical Research Council, National Medical Research Council, Biomedical Research Council

Awards: G1415941161, G1739064799, G3467955609, G5546802662, G6035246938

OpenAlex ID: W4377966043

FWCI: 0.85

Cites: 27

Cited by: 11

Related to: 10