A high-fat diet increases hepatic mitochondrial turnover through restricted acetylation in a NAFLD mouse model
Year: 2023
Type: article
Abstract: This is the first method to quantify acetylome dynamics in vivo. This method revealed acetylation-mediated altered hepatic mitochondrial protein turnover in response to a high-fat diet in a mouse model of NAFLD.
Authors: Mirjavid Aghayev, Andrea Arias-Alvarado, Sergei Ilchenko, Josephine Lepp, Iain Scott, Yeong-Renn Chen, Guo-Fang Zhang, Tsung-Heng Tsai, Takhar Kasumov
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Rates of brain acetylome remodeling in a mouse model of diabetes and tauopathy, Follistatin-like protein 1 in cardiac and systemic metabolism, Novel computational methods for in vivo proteome dynamics estimation using heavy water metabolic labeling and LC-MS, Mitochondrial Acetylation and Acetylome Dynamics in Alcoholic Liver Disease assessed with Heavy Water, Novel strategies to resolve metabolic defects in the diabetic heart, Mitochondrial Proteome Dynamics in Heart Failure Assessed with Heavy Water, Fatty acid oxidation in female cardioprotection, NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology
OpenAlex ID: W4377967626