Year: 2023
Type: article
Abstract: The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins invokes derivation from unpaired median fins via a pair of lateral fin folds located between pectoral and pelvic fin territories 1 . Whilst unpaired and paired fins exhibit similar structural and molecular characteristics, no definitive evidence exists for paired lateral fin folds in larvae or adults of any extant or extinct species. As unpaired fin core components are regarded as exclusively derived from paraxial mesoderm, any transition presumes both co-option of a fin developmental programme to the LPM and bilateral duplication 2 . Here, we identify that the larval zebrafish unpaired pre-anal fin fold (PAFF) is derived from the LPM and thus may represent a developmental intermediate between median and paired fins. We trace the contribution of LPM to the PAFF in both cyclostomes and gnathostomes, supporting the notion that this is an ancient trait of vertebrates. Finally, we observe that the PAFF can be bifurcated by increasing bone morphogenetic protein signalling, generating LPM-derived paired fin folds. Our work provides evidence that lateral fin folds may have existed as embryonic anlage for elaboration to paired fins.
Source: Nature
Authors: Keh-Weei Tzung, Robert L. Lalonde, Karin D. Prummel, Harsha Mahabaleshwar, Hannah R. Moran, Jan Stundl, Amanda N. Cass, Yao Le, Robert Lea, Karel Dorey, Monika J. Tomecka, Changqing Zhang, Eline C. Brombacher, William T. White, Henry H. Roehl, Frank J. Tulenko, Christoph Winkler, Peter D. Currie, Enrique Amaya, Marcus C. Davis, Marianne E. Bronner, Christian Mosimann, Tom J. Carney
Institutions: Agency for Science, Technology and Research, Nanyang Technological University, Institute of Molecular and Cell Biology, University of Colorado Anschutz, University of Zurich, California Institute of Technology, University of South Bohemia in České Budějovice, Wesleyan University, National University of Singapore, University of Manchester, Commonwealth Scientific and Industrial Research Organisation, Australian National Fish Collection, University of Sheffield, Australian Regenerative Medicine Institute, Monash University, EMBL Australia, Western New England University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $11,690
Funders: National Science Foundation, Children's Hospital Colorado, Additional Ventures, Company of Biologists, Agency for Science, Technology and Research, Nanyang Technological University, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Ministry of Education, India, Swiss Bridge Foundation, National Institutes of Health, Medical Research Council, Biotechnology and Biological Sciences Research Council, Australian Research Council, National Health and Medical Research Council, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, University of Colorado School of Medicine, Anschutz Medical Campus
Awards: G1027241741, Predoctoral Training in the Genetics of Development, Disease and Regeneration, G1503466043, G1702991928, G1760975967, Genetic basis for skeletal muscle formation and regeneration in development and disease, G3048563442, G5403095142, Investigating the regulation of chromatin associated proteins by intrinsically disordered regions, Fins to Limbs: Investigating the Evolution of complex Limb Musculature, Chemical modulation of bromodomain function in development and disease, Defining the developmental mechanisms of pericardium formation, RUI: Evolutionary origins of the vertebrate paired appendage gene regulatory network, G9000033003
OpenAlex ID: W4377982097