Work

Author response: Mitochondrial protein import clogging as a mechanism of disease

Year: 2023

Type: peer-review

Abstract: Missense mutations in the nuclear-encoded adenine nucleotide translocase 1 (Ant1) cause the protein to clog the mitochondrial protein import pathway, to severely inhibit cell growth in yeast, and to cause neurodegeneration and myopathy in mice that phenocopy ANT1-induced human disease.

Source: eLife

DOI: 10.7554/elife.84330.sa2

Authors: Liam P Coyne, Xiaowen Wang, Jiyao Song, Ebbing de Jong, Karin Schneider, Paul T Massa, Frank A Middleton, Thomas Becker, Xin Jie Chen

Institutions: SUNY Upstate Medical University, University of Bonn, University of Freiburg

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4377982266

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