Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery
Year: 2023
Type: article
Abstract: Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2–7 years), children and adolescents (8–18 years), adults (19–59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4–5.0]) and very young children (4.0% [3.4–5.2]), followed by adults (2.7% [1.7–4.0]), and older adults (1.8% [1.2–2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight–05:59) was lower than during daytime (06:00–23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups.
Authors: Heba Alwan, Julia Ware, Charlotte K. Boughton, Malgorzata E. Wilinska, Janet M. Allen, Rama Lakshman, Munachiso Nwokolo, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E.J. Besser, Fiona M. Campbell, Nikki Davis, Louise Denvir, Mark L. Evans, Elke Fröhlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Parth Narendran, Birgit Rami-Mehrar, Martin Tauschmann, Hood Thabit, Ajay Thankamony, Roman Hovorka, on behalf of the AP@home, DAN05, DAN06 and KidsAP Consortia
Institutions: University of Bern, University of Cambridge, Wellcome/MRC Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, University Hospital of Bern, Centre Hospitalier de Luxembourg, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Leeds Teaching Hospitals NHS Trust, Southampton Children's Hospital, Nottingham University Hospitals NHS Trust, Medical University of Graz, Alder Hey Children's NHS Foundation Trust, Alder Hey Children's Hospital, Innsbruck Medical University, University Hospital Leipzig, Leipzig University, University of Manchester, Manchester University NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, University of Birmingham, Medical University of Vienna
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: National Science Foundation, Eli Lilly and Company, Sanofi, Leona M. and Harry B. Helmsley Charitable Trust, Wellcome Trust, Insulet Corporation, Dexcom, National Institute for Health and Care Research, University of Cambridge, European Commission, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Novo Nordisk, Servier, Roche Diabetes Care, Abbott Diabetes Care, NIHR Cambridge Biomedical Research Centre, National Institute of Diabetes and Digestive and Kidney Diseases, NIHR Evaluation Trials and Studies Coordinating Centre
Awards: G10500178, Subclinical thyroid dysfunction and the development of non-communicable diseases: a Mendelian randomization study, G2166940007, 24/7 closed-loop in older subjects with type 1 diabetes, One year day-and-night home closed loop in young people with type 1 diabetes, Effect of closed loop insulin delivery from onset of diabetes in youth on progression of type 1 diabetes, G8589133502, G8758826526, The artificial pancreas in children aged 1 to 7 years with type 1 diabetes
OpenAlex ID: W4378194058