Year: 2023
Type: editorial
Abstract: Peripheral arterial disease (PAD) affects 10 million people in the US and more than 230 million worldwide 1,2 .It is associated with impaired vascular perfusion to the lower extremities, leading to limb-threatening amputation in severe cases of critical limb ischemia.PAD patients have an inferior prognosis and reduced limb function, when compared to patients without PAD 3 .Very few effective therapies have been identified, in part because the key biologic pathways associated with functional impairment remain unclear.Current treatments include supervised and home-based walking exercise to improve the mobility in PAD patients 4,5 .A better understanding of the underlying pathological mechanisms of skeletal muscle damage underlying PAD may help identify new therapeutic opportunities.
Source: Circulation Research
Authors: Ishita Jain, Beu P. Oropeza, Ngan F. Huang
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1207582519, iPSC-Derived Smooth Muscle Progenitors in Elastin Hydrogels for Treating Abdominal Aortic Aneurysm, Aligned Nanofibrillar Scaffolds Enhance Angiogenesis and Viability in Ischemia, Injectable Hydrogels to Deliver Gene Therapy for Myocardial Infarct, Substrate Stiffness Modulates Endothelial-to-Mesenchymal Transition, Engineered matrix microarrays to enhance the regenerative potential of iPSC-derived endothelial cells, G4586000846, G5160892468, G5792377579, ISS: Tissue Engineered Muscle in Microgravity as a Novel Platform to Study Sarcopenia, G794180464, G8195136211, BRITE Pivot: Engineered Extracellular Matrix Cues Affecting Endothelial Phenotypic Change
OpenAlex ID: W4378194963