Work

Toward a deeper understanding of gene-by-sex interaction models

Year: 2023

Type: article

Abstract: propose amplification as the primary mode for gene-by-sex interactions in complex traits. Khramtsova et al. preview their modeling approach and discuss implications for the future work on the genomics of sex differences.

Source: Cell Genomics

DOI: 10.1016/j.xgen.2023.100324

Authors: Ekaterina A. Khramtsova, Stacey J. Winham, Lea K. Davis, Barbara E. Stranger, Melissa A. Wilson

Institutions: Janssen Research & Development (United States), Mayo Clinic, Vanderbilt University Medical Center, Northwestern University, Arizona State University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $8,900

Funders: National Institutes of Health, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: Genetic mechanisms underlying sexual dimorphism in cancer and response to therapy, Elucidating the phenome-wide impact of sex and gender on disease, Population dynamics and medical consequences of sex chromosome evolution

OpenAlex ID: W4378349036

FWCI: 0.497

Cites: 8

Cited by: 3

Related to: 10