Year: 2023
Type: editorial
Abstract: Insights in cell growth and divisionThe Research Topic "Insights in Cell Growth and Division" is a collection of articles published in the Cell Growth and Division section of Frontiers in Cell and Developmental Biology (https://www.frontiersin.org/journals/cell-and-developmental-biology).Since this journal views the topic of cell and developmental biology quite broadly, it only makes sense that the articles cover a lot of ground.This includes ovarian primordial-to primary follicle transition, DNA damage checkpoint, neural stem cell cycle regulators, asymmetric cell division, the mammary gland, protein degradation, functions of centrosomes, tumor suppressors, centrioles, and genome and chromosome stability (for more detail see below).While, several articles deal with cell cycle in the broadest sense, others focus on development.For example, Thompson et at.discuss the functions of SKP1, a component of the SCF (SKP1, Cullin 1, F-box protein) complex in genome and chromosome stability and how it relates to cancer.Following a similar path, Guerber et al. present an overview of the Ubiquitin Binding Protein 2-Like (UBAP2L), which plays several roles in cancer including promoting cell proliferation, growth, EMT, migration, invasion, metastasis, vascularization, and survival.Centrioles form centrosomes and are important components of cells, which is the topic of two reviews.Langlois-Lemay and D'Amours discuss the functions of centrosomes beyond their traditional role of microtubule organizing centers touching on cell cycle progression, DNA damage, sensory reception, and cell homeostasis.Avidor-Reiss et al. investigate the functions of centrioles in male fertility in a variety of mammals.Continuing with the theme of fertility, Ataei- Nazari et al. studied the functions of CDK6, a well-known cell cycle regulator, in oocyte development and define a new role for CDK6 in the primordial-to-primary transition.Lee reviews the mammary gland in regard to shared pathways in embryonic mammary gland cells and breast cancer.There are three articles related to cell cycle regulation including the DNA damage checkpoint, asymmetric cell division, and neural stem cell cycle regulators.Yam et al. describe a DNA damage checkpoint at the G2/M transition with regards how it engages and how it is switched off.Mistakes in this checkpoint leads to adaptation where the cells continue to divide despite the damage.Li et al. discuss asymmetric cell division which plays an important role in stem cells.They focus on cancer stem cells and whether asymmetric cell division contributes to tumor heterogeneity and cancer progression.Caron et al. review neural stem cell cycle regulators in zebrafish.Zebrafish is an excellent model system to study
Author: Philipp Kaldis
Institution: Lund University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4378349346