Work

Role of Midkine in Cancer Drug Resistance: Regulators of Its Expression and Its Molecular Targeting

Year: 2023

Type: review

Abstract: Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers and indicates its association with multi-drug resistance in cancer. MDK, a secretory cytokine found in blood, can be exploited as a potent biomarker for the non-invasive detection of drug resistance expressed in various cancers and, thereby, can be targeted. We summarize the current information on the involvement of MDK in drug resistance, and transcriptional regulators of its expression and highlight its potential as a cancer therapeutic target.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms24108739

Authors: Minakshi Saikia, Nathan Cheung, Abhay Kumar Singh, Vaishali Kapoor

Institutions: Washington University in St. Louis, Alvin J. Siteman Cancer Center

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,780