Year: 2023
Type: article
Abstract: OBJECTIVE: Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight the sensitivity of learning slopes to discriminate disease severity in cognitively normal participants and those diagnosed with early-onset dementia with and without β-amyloid positivity METHOD: Data from 310 participants in the Longitudinal Early-Onset Alzheimer's Disease Study (aged 41 to 65) were used to calculate learning slope metrics. Learning slopes among diagnostic groups were compared, and the relationships of slopes with standard memory measures were determined RESULTS: Worse learning slopes were associated with more severe disease states, even after controlling for demographics, total learning, and cognitive severity. A particular metric-the learning ratio (LR)-outperformed other learning slope calculations across analyses CONCLUSIONS: Learning slopes appear to be sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The LR may be the learning measure of choice for such analyses. HIGHLIGHTS: Learning is impaired in amyloid-positive EOAD, beyond cognitive severity scores alone. Amyloid-positive EOAD participants perform worse on learning slopes than amyloid-negative participants. Learning ratio appears to be the learning metric of choice for EOAD participants.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13159
Authors: Dustin B. Hammers, Sára Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff‐Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Steve Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra Weintraub, Thomas S. Wingo, David A. Wolk, Bonnie Wong, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova
Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Brown University, University of Southern California, University of California, San Francisco, Banner Sun Health Research Institute, Mayo Clinic, Mayo Clinic in Florida, Mount Sinai Medical Center, Columbia University Irving Medical Center, Houston Methodist, Weill Cornell Medicine, University of California, Los Angeles, Washington University in St. Louis, Johns Hopkins University, Johns Hopkins Medicine, Northwestern University, Stanford University, Georgetown University, Emory University, University of Pennsylvania, Harvard University, Massachusetts General Hospital, Alzheimer's Association
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1017046091, G1024368718, G1048051091, G1106781614, G1171648585, G1173778324, G1253289787, G1263262031, G1309605592, Indiana Alzheimer Disease Center, G1369195717, G1475322558, G1614502467, G1734698810, G1753564228, G1786295724, G1835837428, G1859882300, G2190936067, G2272057415, G234895681, G2672089175, G2769554943, G282710236, Early Onset AD Consortium - the LEAD Study (LEADS), G2929235049, G3026342146, National Alzheimer's Coordinating Center, G3308348438, G3335858628, G3425837580, G36881302, G3703765782, G3727582191, G3842034552, G3919444319, G40706755, G4082276054, Alzheimer's Disease Core Center, G4393308642, G4417220376, G445099135, G468709790, The Role of Copy Number Variants and Epigenetic Dysregulation in Early Onset Alzheimer’s Disease (EOAD), G504619356, Behavioral Interventions for the Treatment of Early Onset AD, G556672640, G603598372, G639043084, G6425121803, G6445626367, G6492025387, Indiana University LEADS Diversity Recruitment Supplement, G6876577119, Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, G7176475171, G76412088, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, G816726602, G8620018032, G873702183, G8924848700, Alzheimer's Disease Research Center, Arizona Alzheimer's Disease Research Center, Stanford Alzheimer's Disease Research Center, Penn Alzheimer's Disease Research Center (ADRC), National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Massachusetts Alzheimer's Disease Research Center (MADRC)
OpenAlex ID: W4378549199