Year: 2023
Type: article
Abstract: Recent therapeutic advances provide heightened motivation for accurate diagnosis of the underlying biologic causes of dementia. This review focuses on the importance of clinical recognition of limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE affects approximately one-quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co-occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (Aβ amyloid/tau vs TDP-43). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. ANN NEUROL 2023;94:211-222.
Source: Annals of Neurology
DOI: 10.1002/ana.26711
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,610
Awards: G1020749929, G1069732457, G1224480130, G1480831932, G1531775036, G1635571750, G1975182019, G2142763156, G2312590700, G2742075923, G288296383, G4559892875, G504619356, G5527224736, G7911027991, Modulators of Medial Temporal Lobe Subregion Structure and Function in Normal and Pathological Aging, Genetic Architecture of Aging-Related TDP-43 and Mixed Pathology Dementia, G9000004438, G9000011571, G9000015010, G9000040117, G9000047451, G9000049848, G9000065952, G9000137862, G9000167254, G9000179856, G9000197435, G9000211219, G9000243838, G9000254440, G929541364
OpenAlex ID: W4378569287