GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Year: 2024
Type: article
Authors: Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R. Palicharla, Samuel P. Berry, Philipp Tschaikner, Dominik Regele, Douglas F. Covey, Eduard Stefan, Debora S. Marks, Jeremy F. Reiter, Ron O. Dror, Alex S. Evers, Saikat Mukhopadhyay, Aashish Manglik
Institutions: University of California, San Francisco, The University of Texas Southwestern Medical Center, Washington University in St. Louis, Taylor Family Institute for Innovative Psychiatric Research, Stanford Medicine, Stanford University, Harvard University, Universität Innsbruck, Tyrolean Cancer Research Institute, Chan Zuckerberg Biohub San Francisco
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Health and Human Services, Vallee Foundation, Edward Mallinckrodt, Jr. Foundation, Human Frontier Science Program, National Institutes of Health, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, SLAC National Accelerator Laboratory, Common Fund
Awards: Molecular Biophysics Training Grant, Molecular Biophysics Training Grant, Transition zone control of ciliary signaling, Glacios™ Cryo Transmission Electron Microscope with 200 kV XFEG optics, The Stanford-SLAC CryoEM Center, G2940984693, Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium, Acquisition of an electron microscope for high-resolution single particle cryo-EM, G4582703735, G4670082738, G5832064650, Discovering the mechanism of GPCR-mediated arrestin stimulation to enable effective drug therapies, Understanding Ciliary Functions in Mammalian Development, G6913084647, G6999390677, Molecular Sites of Neurosteroid Binding, G7557693556, Molecular mechanisms of proton-sensing in CO2-dependent breathing, G7655511949, Linux cluster for near atomic resolution single particle cryo-EM, G8886052784, Mechanisms of Smoothened Activation in Hedgehog Signaling, Signaling at the primary cilium in development and disease, Molecular Biophysics Training Grant, Neurosteroid and Cholesterol Binding to Integral Membrane Proteins, Neuroactive steroids as novel psychiatric treatments: mechanistic studies
OpenAlex ID: W4391630648