Work

0878 Sleep Measures Worsen for Individuals who are Obese but Improve for Individuals who are not Obese from 60-90days after Stroke

Year: 2023

Type: article

Abstract: Introduction Goals of post-stroke rehabilitation include recovery of physical function which, in turn, relies on motor learning to relearn functional skills. Given the known association between motor learning and sleep, it is important to understand if sleep is related to characteristics of persons with stroke (PwS) during the subacute timeframe (60–90 days following stroke) to potentially guide interventions. Obesity is a known risk-factor for stroke and therefore prevalent among PwS. The purpose of this study was to determine if there are differences between changes in objectively measured sleep parameters across the 60-90 day post-stroke period that correspond to different levels of body mass index (BMI). Methods PwS received standard of care for post-stroke physical rehabilitation, and wore wrist actigraphy for 3-9nights at 60 and 90 days post-stroke, with no additional interventions. Total sleep time (TST), time in bed (TIB), sleep efficiency (SE), sleep latency (SL), wake after sleep onset (WASO), number of awakenings (NWAK) and average time per awakening (TPA) were obtained from the actigraphy software for each night, and average nightly values determined. Participants were categorized into two groups based on BMI (< 30 and >=30). Changes were calculated as 90-day minus 60-day values. Independent samples t-tests were performed to determine if there were differences in changes in sleep parameters between BMI groups. Results The PwS sample (n=31, 52% female, average age 66.7years, range 44–85+) included n=13 with BMI >=30. Independent t-tests found a significant difference in change in SE (6.9%, p=0.016) and change in NWAK (6.3, p=0.003) between the two groups. For those with BMI>=30 SE and NWAK worsened from 60-90-days following stroke (-4.2% and 2counts), whereas for those with BMI< 30 SE and NWAK improved (+2.7% and -4.3counts). No significant differences were found between groups for changes in TST, TIB, SL, WASO or TPA. Conclusion Without sleep-related interventions, sleep characteristics worsen for PwS who are obese in the subacute post-stroke recovery phase, but improves for PwS who are not obese. There may be opportunities to explore sleep-related interventions for PwS who are obese. Support (if any) This study was supported by NINR Award Number R01 NR018979.

Source: SLEEP

DOI: 10.1093/sleep/zsad077.0878