Work

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Year: 2023

Type: review

Abstract: The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

Source: Experimental & Molecular Medicine

DOI: 10.1038/s12276-023-01004-1

Authors: Kyung Ah Han, Jaewon Ko

Institution: Daegu Gyeongbuk Institute of Science and Technology

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,290

Funders: National Research Foundation, National Research Foundation of Korea, Ministry of Science and ICT, South Korea