Work

Sertoli-Leydig cell tumor associated with a germline DICER1 pathogenic variant diagnosed during pregnancy: Considerations for treatment, surveillance, and prevention

Year: 2023

Type: article

Abstract: • This is the first report of a germline DICER1 -associated Sertoli-Leydig cell tumor (SLCT) diagnosed in pregnancy. • SLCT is linked to DICER1 pathogenic variants, but little is known about management of DICER1 -associated SLCT. • There is an extended risk for metachronous SLCT in patients with germline DICER1 pathogenic variants who retain an ovary. • Prophylactic contralateral salpingo-oophorectomy may be offered with shared decision making to patients with inherited SLCT. • Genetic testing for DICER1 should be offered to all patients with moderately or poorly differentiated SLCT.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2023.101215

Authors: Joyce Y. Wang, Kimberly K. Ma, Daniel J. Reiter, Ana Torvie, Elizabeth M. Swisher

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $750